Transcriptomics,Genomics

Dataset Information

297

The Obesity-associated Fto gene regulates activity of the dopaminergic midbrain circuitry [FTO KO]


ABSTRACT: Here we use MeRIP-Seq to analyze global adenosine methylation (m6A) in mRNAs in the midbrain and striatum of Fto-deficient mice. We find that Fto deficiency leads to increased methylation within a subset of mRNAs important for neuronal signaling, including many within the dopaminergic signaling pathway. Collectively, our results show that Fto regulates demethylation of specific mRNAs in vivo, and this activity relates to control of dopaminergic transmission. Profiling of m6A in midbrain and striatum from FTO knockout mice

ORGANISM(S): Mus musculus  

SUBMITTER: Olivier Elemento   Tamas L Horvath  Marcelo O Dietrich  Linda Koch  Simon Hess  Martin E Hess  Linda A Verhagen  Christopher Mason  Samie R Jaffrey  Bengt F Belgardt  Jens C Brüning  Hella S Brönneke  Thomas Franz  Kate D Meyer  Sabine D Jordan  Peter Kloppenburg  Ulrich Rüther 

PROVIDER: E-GEOD-47216 | ArrayExpress | 2013-06-15

SECONDARY ACCESSION(S): GSE47216SRP023107PRJNA205150

REPOSITORIES: GEO, ArrayExpress, ENA

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