Transcriptomics

Dataset Information

31

Microarray expression profiling of Runx1-null and wildtype mouse mammary epithelial cells


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus  

SUBMITTER: Zhe Li   

PROVIDER: E-GEOD-47377 | ArrayExpress | 2014-11-28

SECONDARY ACCESSION(S): GSE47377PRJNA205360

REPOSITORIES: GEO, ArrayExpress

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Publications

RUNX1, a transcription factor mutated in breast cancer, controls the fate of ER-positive mammary luminal cells.

van Bragt Maaike P A MP   Hu Xin X   Xie Ying Y   Li Zhe Z  

eLife 20141121


RUNX1 encodes a RUNX family transcription factor (TF) and was recently identified as a novel mutated gene in human luminal breast cancers. We found that Runx1 is expressed in all subpopulations of murine mammary epithelial cells (MECs) except the secretory alveolar luminal cells. Conditional knockout of Runx1 in MECs by MMTV-Cre led to a decrease in luminal MECs, largely due to a profound reduction in the estrogen receptor (ER)-positive mature luminal subpopulation, a phenotype that could be res  ...[more]

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