Transcriptomics

Dataset Information

298

The star-nosed mole reveals clues to the molecular basis of mammalian touch.


ABSTRACT: Little is known about the molecular mechanisms underlying mammalian touch transduction. To identify novel candidate transducers, we examined the molecular and cellular basis of touch in one of the most sensitive tactile organs in the animal kingdom, the star of the star-nosed mole. Our findings demonstrate that the trigeminal ganglia innervating the star are enriched in tactile-sensitive neurons, resulting in a higher proportion of light touch fibers and lower proportion of nociceptors compared to the dorsal root ganglia innervating the rest of the body. We exploit this difference using transcriptome analysis of the star-nosed mole sensory ganglia to identify novel candidate mammalian touch and pain transducers. The most enriched candidates are also expressed in mouse somatosesensory ganglia, suggesting they may mediate transduction in diverse species and are not unique to moles. These findings highlight the utility of examining diverse and specialized species to address fundamental questions in mammalian biology. Examination of the transcriptome of 3 trigeminal and 3 dorsal root ganglia

SUBMITTER: Maurizio Pellegrino   Takeshi Morita  Kristin A Gerhold  Makoto Tsunozaki  Pamela R Tsuruda  Diana M Bautista  Duncan B Leitch  Rachel B Brem  Kenneth C Catania 

PROVIDER: E-GEOD-47480 | ArrayExpress | 2013-05-31

SECONDARY ACCESSION(S): SRP023348GSE47480PRJNA205891

REPOSITORIES: GEO, ArrayExpress, ENA

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Little is known about the molecular mechanisms underlying mammalian touch transduction. To identify novel candidate transducers, we examined the molecular and cellular basis of touch in one of the most sensitive tactile organs in the animal kingdom, the star of the star-nosed mole. Our findings demonstrate that the trigeminal ganglia innervating the star are enriched in tactile-sensitive neurons, resulting in a higher proportion of light touch fibers and lower proportion of nociceptors compared  ...[more]

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