Transcriptomics

Dataset Information

6

Subventricular zone progenitors healthy vs. Experimental Autoimmune Encephalomyelitis mice


ABSTRACT: Transcriptional profiling of subventricular zone (SVZ) progenitors comparing control healthy mice to mice induced to develop an autoimmune demyelination (EAE model). Goal was to unveil genes involved in demyelination-induced reactivity of SVZ progenitors. Two-condition experiment, healthy vs. EAE derived SVZ progenitors. Biological replicates: 2 control replicates, 2 EAE replicates. SVZ progenitors were sorted in two cell populations: neuronal progenitors (PSA-NCAM magnetic sorting) and glial progenitors (NG2 magnetic sorting). Progenitors from healthy mice are reference samples.

ORGANISM(S): Mus musculus  

SUBMITTER: Myriam Cayre  Pascale Durbec   Myriam CAYRE   Cristina Cantarella    

PROVIDER: E-GEOD-47486 | ArrayExpress | 2014-06-03

SECONDARY ACCESSION(S): GSE47486PRJNA205859

REPOSITORIES: GEO, ArrayExpress

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Publications

Netrin 1 contributes to vascular remodeling in the subventricular zone and promotes progenitor emigration after demyelination.

Cayre Myriam M   Courtès Sandrine S   Martineau Fanny F   Giordano Marilyn M   Arnaud Karen K   Zamaron Amandine A   Durbec Pascale P  

Development (Cambridge, England) 20130703 15


Neural stem cells are maintained in the adult brain, sustaining structural and functional plasticity and to some extent participating in brain repair. A thorough understanding of the mechanisms and factors involved in endogenous stem/progenitor cell mobilization is a major challenge in the promotion of spontaneous brain repair. The main neural stem cell niche in the adult brain is the subventricular zone (SVZ). Following demyelination insults, SVZ-derived progenitors act in concert with oligoden  ...[more]

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