Transcriptomics,Genomics

Dataset Information

0

Gata6


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Musculus  

SUBMITTER: Enrique Carrillo de Santa Pau   FX Real  P Martinelli  E Carrillo de Santa Pau 

PROVIDER: E-GEOD-47537 | ArrayExpress | 2015-02-03

SECONDARY ACCESSION(S): GSE47537PRJNA205989

REPOSITORIES: GEO, ArrayExpress

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Publications

The acinar regulator Gata6 suppresses KrasG12V-driven pancreatic tumorigenesis in mice.

Martinelli Paola P   Madriles Francesc F   Cañamero Marta M   Pau Enrique Carrillo-de Santa EC   Pozo Natalia Del ND   Guerra Carmen C   Real Francisco X FX  

Gut 20150116 3


Gata6 is required to complete and maintain acinar differentiation in the mouse pancreas. Pancreas-specific Gata6 ablation during development causes extensive and persistent acinar-ductal metaplasia, which is considered an initial step of mutant KRas-driven carcinogenesis. Therefore, the Gata6-null pancreas might represent a tumour-prone environment. We investigated whether Gata6 plays a role during pancreatic tumorigenesis.We analysed genetically engineered mouse models and human pancreatic duct  ...[more]

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