Transcriptomics

Dataset Information

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The genomic and transcriptomic dynamics of treatment-naïve epithelial ovarian cancer


ABSTRACT: We reveal three-dimensional patterns of tumour growth by exploiting the unique metastasizing patterns of treatment naïve stage IIIC/IV epithelial ovarian cancer. We performed topographic mapping of structural genomic rearrangements, coding mutations, copy number changes and RNA expression in biopsies derived from 27 primary and metastatic sites across three patients. Based on somatic genomic changes, we performed sample clustering and obtained unique insight in natural tumour growth and spread. Based on extensive multi-level profiling, our data highlight the diverse modes of epithelial ovarian cancer development before applying selective pressure from therapy. We performed SNP array analysis on tumor biopsies from 3 patients (P1, P2, P3) with advanced stage ovarian cancer. This submission includes SNP data for 26 tumor biopsies and 5 normal tissue samples.

ORGANISM(S): Homo sapiens  

SUBMITTER: Wigard Kloosterman   Marlous Hoogstraat  Tanisha Guy  Martijn Lolkema  Tim Harkins  Ivo Renkens  Clarence Lee  Jennifer Kreeftmeijer  Marco Koudijs  Geert Cirkel  Mirjam de Pagter  Isaac J Nijman  Wigard P Kloosterman  Karen Duran  Edwin Cuppen  Ronald Zweemer  Ruben van 't Slot  Els P Witteveen  Trudy Jonges  Emile Voest  Markus J van Roosmalen 

PROVIDER: E-GEOD-47633 | ArrayExpress | 2013-06-05

SECONDARY ACCESSION(S): GSE47633PRJNA206966

REPOSITORIES: GEO, ArrayExpress

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