Transcriptomics

Dataset Information

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Gene expression profiles of Hodgkin’s lymphoma cells


ABSTRACT: By using high-density DNA microarrays, we analyzed the gene-expression profile of Hodgkin's lymphoma cell lines. RNA was extracted from established Hodgkin's lymphoma cell lines and analyzed with Affymetrix Human Exon 1.0ST microarrays.

ORGANISM(S): Homo sapiens  

SUBMITTER: Martin S Staege   Martin Sebastian Staege  Stefanie Kewitz  Julia Müller 

PROVIDER: E-GEOD-47686 | ArrayExpress | 2013-07-16

SECONDARY ACCESSION(S): GSE47686PRJNA207294

REPOSITORIES: GEO, ArrayExpress

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Publications

Expression and Regulation of the Endogenous Retrovirus 3 in Hodgkin's Lymphoma Cells.

Kewitz Stefanie S   Staege Martin Sebastian MS  

Frontiers in Oncology 20130710


Human endogenous retroviruses (ERV) are an integral part of our genome. Expression of ERV is usually switched off but reactivation of ERV has been observed in varying human diseases including cancer. Recently, reactivation of ERV associated promoters in Hodgkin's lymphoma (HL) cells has been described. Despite relatively good prognosis, not all patients with HL can be cured with the established therapy and this therapy is associated with severe late side effects. Therefore, new targets are requi  ...[more]

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