Dataset Information


Early life stress in fathers impairs synaptic plasticity in the offspring - brain collected at rest

ABSTRACT: We show that traumatic stress experienced by males in early postnatal life impairs memory in their offspring, blocks long-term potentiation (LTP) and favors long-term depression (LTD). These effects are accompanied by suppression of key molecular pathways involved in neuronal plasticity both at rest and after acute stress. Male mice were exposed to chronic traumatic stress in early postnatal life and were later bred to naïve females to produce second-generation offspring. Memory performance was evaluated in the offspring, and synaptic plasticity was examined in the hippocampus and the amygdala, brain areas important for memory formation. The two groups tested were 1: offspring of fathers which were stressed (MSUS - maternal separation unpredictable stress) and 2: offspring of non-stressed fathers (control). Genome-wide gene expression in hippocampus of these two groups was assessed at rest (this study) and after acute stress.

ORGANISM(S): Mus musculus  

SUBMITTER: Iniguez A Leonardo   Ebeling Martin  Gapp Katharina  Kashuk Carl  Mansuy Isabelle M  Steiner Guido  Bohacek Johannes  Guido Steiner  Moreau Jean-Luc  Duran P Gonzalo  Mirante Osvaldo  Coiret Guyllaume  Farinelli Melissa  Manuella Francesca 

PROVIDER: E-GEOD-47846 | ArrayExpress | 2014-07-01



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