Transcriptomics

Dataset Information

10

Expression data from cultured human ovarian carcinoma cell lines with and without Cisplatin treatment


ABSTRACT: Chemo-resistance to platinum such as cisplatin is critical in the treatment of ovarian cancer. Recent evidences have linked epithelial-mesenchymal transition (EMT) with the drug resistance as a contributing mechanism. The current study explored the connection between cellular responses to cisplatin with EMT in ovarian cancer. 46 ovarian carcinoma cell lines expression data with and without Cisplatin treatment.

ORGANISM(S): Homo sapiens  

SUBMITTER: Seiichi Mori   Tuan Z Tan  Tuan Zea Tan  Qing E Miao  Jean P Thiery 

PROVIDER: E-GEOD-47856 | ArrayExpress | 2014-07-29

SECONDARY ACCESSION(S): GSE47856PRJNA208085

REPOSITORIES: GEO, ArrayExpress

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Publications

Epithelial-mesenchymal status renders differential responses to cisplatin in ovarian cancer.

Miow Q H QH   Tan T Z TZ   Ye J J   Lau J A JA   Yokomizo T T   Thiery J-P JP   Mori S S  

Oncogene 20140526 15


Chemoresistance to platinums, such as cisplatin, is of critical concern in the treatment of ovarian cancer. Recent evidence has linked epithelial-mesenchymal transition (EMT) as a contributing mechanism. The current study explored the connection between cellular responses to cisplatin and EMT in ovarian cancer. Expression microarrays were utilized to estimate the EMT status as a binary phenotype, and the transcriptional responses of 46 ovarian cancer cell lines to cisplatin were measured at dosa  ...[more]

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