Transcriptomics

Dataset Information

4

The 5p12 breast cancer susceptibility locus affects MRPS30 expression in estrogen-receptor positive tumors


ABSTRACT: Uninvolved tissue taken at the time of primary surgical resection of an adenocarcinoma. Uninvolved status determined by surgical margin and gross appearance, not pathology 35 biologically distinct samples, no replicates, no controls

ORGANISM(S): Homo sapiens  

SUBMITTER: Vessela Kristensen   David A Quigley  Ida R Bukholm  David Quigley 

PROVIDER: E-GEOD-48067 | ArrayExpress | 2014-05-22

SECONDARY ACCESSION(S): GSE48067PRJNA208848

REPOSITORIES: GEO, ArrayExpress

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Publications


Genome-wide association studies have identified numerous loci linked to breast cancer susceptibility, but the mechanism by which variations at these loci influence susceptibility is usually unknown. Some variants are only associated with particular clinical subtypes of breast cancer. Understanding how and why these variants influence subtype-specific cancer risk contributes to our understanding of cancer etiology. We conducted a genome-wide expression Quantitative Trait Locus (eQTL) study in a d  ...[more]

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