Transcriptomics

Dataset Information

4

PSN1 Polysome and INK128


ABSTRACT: Polysome-bound mRNA was analyzed to determine the effects of INK128 and radiation on mRNA translation 4 samples were analyzed with 3 biological replicates

ORGANISM(S): Homo sapiens  

SUBMITTER: Uma T Shankavaram   Philip Tofilon  Tamalee Kramp  Thomas J Hayman  Kevin Camphausen  Philip J Tofilon  Muhammad Jamal  Heekyong Bae 

PROVIDER: E-GEOD-48098 | ArrayExpress | 2014-02-03

SECONDARY ACCESSION(S): GSE48098PRJNA208930

REPOSITORIES: GEO, ArrayExpress

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Publications

The ATP-competitive mTOR inhibitor INK128 enhances in vitro and in vivo radiosensitivity of pancreatic carcinoma cells.

Hayman Thomas J TJ   Wahba Amy A   Rath Barbara H BH   Bae Heekyong H   Kramp Tamalee T   Shankavaram Uma T UT   Camphausen Kevin K   Tofilon Philip J PJ  

Clinical cancer research : an official journal of the American Association for Cancer Research 20131106 1


PURPOSE:Radiotherapy remains a primary treatment modality for pancreatic carcinoma, a tumor characterized by aberrant mTOR activity. Given the regulatory role of mTOR in gene translation, in this study, we defined the effects of the clinically relevant, ATP-competitive mTOR inhibitor, INK128 on the radiosensitivity of pancreatic carcinoma cell lines. EXPERIMENTAL DESIGN:Clonogenic survival was used to determine the effects of INK128 on in vitro radiosensitivity of three pancreatic carcinoma cell  ...[more]

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