Transcriptomics

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Transcripyome analysis of Brucella melitensis 16M and otpR mutant using Solexa/Illumina platform


ABSTRACT: We sequenced the mRNA of Brucella melitensis 16M and otpR mutant under acid stress to identify genes that were regulated by regulator OtpR. Examination of mRNA levels in individual sample under acid stress.

ORGANISM(S): Brucella melitensis  

SUBMITTER: Qingmin Wu  

PROVIDER: E-GEOD-48165 | ArrayExpress | 2015-08-11

SECONDARY ACCESSION(S): SRP026210GSE48165PRJNA209085

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications

RNA-seq reveals the critical role of OtpR in regulating Brucella melitensis metabolism and virulence under acidic stress.

Liu Wenxiao W   Dong Hao H   Li Jing J   Ou Qixing Q   Lv Yujin Y   Wang Xiaolei X   Xiang Zuoshuang Z   He Yongqun Y   Wu Qingmin Q  

Scientific reports 20150805


The response regulator OtpR is critical for the growth, morphology and virulence of Brucella melitensis. Compared to its wild type strain 16 M, B. melitensis 16 MΔotpR mutant has decreased tolerance to acid stress. To analyze the genes regulated by OtpR under acid stress, we performed RNA-seq whole transcriptome analysis of 16 MΔotpR and 16 M. In total, 501 differentially expressed genes were identified, including 390 down-regulated and 111 up-regulated genes. Among these genes, 209 were associa  ...[more]

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