Transcriptomics

Dataset Information

0

A novel insulin receptor-binding protein enhances glucose uptake and glucose clearance in vitro and in vivo through triggering insulin receptor signaling pathway


ABSTRACT: In this study, a novel IR-binding protein (IRBP) from Momordica charantia, named as mcIRBP, was identified by analyzing the physical and functional interactions between mcIRBP and IR. The hypoglycemic effect and mechanism of mcIRBP were further evaluated in normal and streptozotocin-induced diabetic mice. Normal and diabetic mice were treated without or with mcIRBP and RNAs from muscle tissues were extracted for microarray analysis. Number of replicate was three.

ORGANISM(S): Mus musculus  

SUBMITTER: Chien-Yun Hsiang   Chia-Cheng Li  Hsin-Yi Lo  Tin-Yun Ho 

PROVIDER: E-GEOD-48274 | ArrayExpress | 2016-06-25

SECONDARY ACCESSION(S): GSE48274PRJNA209692

REPOSITORIES: GEO, ArrayExpress

altmetric image

Publications

A novel insulin receptor-binding protein from Momordica charantia enhances glucose uptake and glucose clearance in vitro and in vivo through triggering insulin receptor signaling pathway.

Lo Hsin-Yi HY   Ho Tin-Yun TY   Li Chia-Cheng CC   Chen Jaw-Chyun JC   Liu Jau-Jin JJ   Hsiang Chien-Yun CY  

Journal of agricultural and food chemistry 20140829 36


Diabetes, a common metabolic disorder, is characterized by hyperglycemia. Insulin is the principal mediator of glucose homeostasis. In a previous study, we identified a trypsin inhibitor, named Momordica charantia insulin receptor (IR)-binding protein (mcIRBP) in this study, that might interact with IR. The physical and functional interactions between mcIRBP and IR were clearly analyzed in the present study. Photo-cross-linking coupled with mass spectrometry showed that three regions (17-21, 34-  ...[more]

Similar Datasets

2015-07-01 | E-GEOD-39689 | ArrayExpress
2014-09-02 | E-GEOD-57771 | ArrayExpress
2014-10-29 | E-GEOD-33565 | ArrayExpress
2012-02-25 | E-GEOD-35934 | ArrayExpress
2012-01-01 | E-GEOD-25208 | ArrayExpress
2015-04-28 | E-GEOD-37677 | ArrayExpress
| GSE67523 | GEO
2010-01-19 | GSE18732 | GEO
2013-06-11 | E-MEXP-3836 | ArrayExpress
2010-05-15 | E-GEOD-18732 | ArrayExpress