Transcriptomics

Dataset Information

3

Interleukin-17 mediated paracrine network promote tumor resistance to anti-angiogenic therapy


ABSTRACT: While angiogenesis inhibitors have provided significant clinical benefit as cancer therapeutics, the mechanisms of anti-VEGF resistance remain incompletely understood. We uncovered an interleukin-17 mediated paracrine network of signaling between the adaptive and innate immune system associated with resistance to anti-VEGF treatment in multiple tumor models. The expression of tumor-associated fibroblasts and tumor-associated granulocytes (defined as CD11b+Gr1+) and tumor-associated monocytic cells (defined as CD11b+Gr1-) were compared between wildtype and IL-17RC knockout tumor bearing mice.

ORGANISM(S): Mus musculus  

SUBMITTER: Zhaoshi Jiang   Alicia Chung  Zora Modrusan  Napoleone Ferrara 

PROVIDER: E-GEOD-48329 | ArrayExpress | 2013-06-27

SECONDARY ACCESSION(S): GSE48329PRJNA209708

REPOSITORIES: GEO, ArrayExpress

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