Transcriptomics

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Response of mammary tissue to high-LET HZE particle (Silicon ions) radiation or low-LET gamma-rays


ABSTRACT: Transcriptional profiling of mammary tissue irradiated at 10 weeks of age with either 100 cGy sparsely ionizing gamma-rays, or 10 cGy or 30 cGy densely ionizing radiation (350 MeV/amu Si). Mammary tissue was collected 1 weeks, 4 weeks, and 12 weeks post-irradiation. Four radiation treatment groups: sham, 100 cGy sparsely ionizing gamma-rays, 10 cGy or 30 cGy densely ionizing radiation (350 MeV/amu Si). Three time points post-irradiation (1, 4, and 12 weeks). Three or four replicates per time point.

ORGANISM(S): Mus musculus  

SUBMITTER: Irineu Bochaca   Mary H Barcellos-Hoff  Haydeliz Martinez-Ruis  Sangeetha Vijayakumar  Jonathan Tang  Jian-Hua Mao  Sylvain V Costes  Ignacio Fernandez-Garcia  David Nguyen 

PROVIDER: E-GEOD-48392 | ArrayExpress | 2013-11-30

SECONDARY ACCESSION(S): GSE48392PRJNA209937

REPOSITORIES: GEO, ArrayExpress

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Publications

Irradiation of juvenile, but not adult, mammary gland increases stem cell self-renewal and estrogen receptor negative tumors.

Tang Jonathan J   Fernandez-Garcia Ignacio I   Vijayakumar Sangeetha S   Martinez-Ruis Haydeliz H   Illa-Bochaca Irineu I   Nguyen David H DH   Mao Jian-Hua JH   Costes Sylvain V SV   Barcellos-Hoff Mary Helen MH  

Stem cells (Dayton, Ohio) 20140301 3


Children exposed to ionizing radiation have a substantially greater breast cancer risk than adults; the mechanism for this strong age dependence is not known. Here we show that pubertal murine mammary glands exposed to sparsely or densely ionizing radiation exhibit enrichment of mammary stem cell and Notch pathways, increased mammary repopulating activity indicative of more stem cells, and propensity to develop estrogen receptor (ER) negative tumors thought to arise from stem cells. We developed  ...[more]

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