Transcriptomics

Dataset Information

4

Differentiation defective phenotypes revealed by large scale analyses of human pluripotent stem cells


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens  

SUBMITTER: Shinya Yamanaka  

PROVIDER: E-GEOD-49053 | ArrayExpress | 2013-12-03

SECONDARY ACCESSION(S): GSE49053PRJNA212780

REPOSITORIES: GEO, ArrayExpress

altmetric image

Publications

Differentiation-defective phenotypes revealed by large-scale analyses of human pluripotent stem cells.

Koyanagi-Aoi Michiyo M   Ohnuki Mari M   Takahashi Kazutoshi K   Okita Keisuke K   Noma Hisashi H   Sawamura Yuka Y   Teramoto Ito I   Narita Megumi M   Sato Yoshiko Y   Ichisaka Tomoko T   Amano Naoki N   Watanabe Akira A   Morizane Asuka A   Yamada Yasuhiro Y   Sato Tosiya T   Takahashi Jun J   Yamanaka Shinya S  

Proceedings of the National Academy of Sciences of the United States of America 20131120 51


We examined the gene expression and DNA methylation of 49 human induced pluripotent stem cells (hiPSCs) and 10 human embryonic stem cells and found overlapped variations in gene expression and DNA methylation in the two types of human pluripotent stem cell lines. Comparisons of the in vitro neural differentiation of 40 hiPSCs and 10 human embryonic stem cells showed that seven hiPSC clones retained a significant number of undifferentiated cells even after neural differentiation culture and forme  ...[more]

Similar Datasets

2013-12-03 | E-GEOD-42448 | ArrayExpress
2014-04-09 | E-GEOD-56606 | ArrayExpress
2013-04-25 | E-GEOD-46364 | ArrayExpress
2016-06-29 | E-GEOD-60923 | ArrayExpress
2016-06-29 | E-GEOD-60816 | ArrayExpress
2016-06-29 | E-GEOD-60821 | ArrayExpress
2013-10-03 | E-GEOD-39279 | ArrayExpress
2014-08-04 | E-GEOD-54848 | ArrayExpress
2012-10-17 | E-GEOD-37965 | ArrayExpress
2016-03-01 | E-GEOD-67393 | ArrayExpress