Dataset Information


Transcriptomic analysis of ERR alpha orphan nuclear receptor

ABSTRACT: Determination of the genes regulated by ERRalpha nuclear receptor in MDA-MB231 cells MDA-MB231 cells were inactivated for ERRalpha using siRNA. Three different siRNAs were used (siE1, siE2, siE3). Cells treated with a control siRNA (siC samples) were used for comparison. Duplicate samples were analyzed. Transcriptomic analysis was performed by RNA-Seq

ORGANISM(S): Homo sapiens  

SUBMITTER: Juliette Sailland   Violaine Tribollet  Jean-Marc Vanacker 

PROVIDER: E-GEOD-49110 | ArrayExpress | 2014-09-17



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Estrogen-related receptor α decreases RHOA stability to induce orientated cell migration.

Sailland Juliette J   Tribollet Violaine V   Forcet Christelle C   Billon Cyrielle C   Barenton Bruno B   Carnesecchi Julie J   Bachmann Alice A   Gauthier Karine Cécile KC   Yu Shan S   Giguère Vincent V   Chan Franky L FL   Vanacker Jean-Marc JM  

Proceedings of the National Academy of Sciences of the United States of America 20141006 42

Several physiopathological processes require orientated cellular migration. This phenomenon highly depends on members of the RHO family of GTPases. Both excessive and deficient RHO activity impair directional migration. A tight control is thus exerted on these proteins through the regulation of their activation and of their stability. Here we show that the estrogen-related receptor α (ERRα) directly activates the expression of TNFAIP1, the product of which [BTB/POZ domain-containing adapter for  ...[more]

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