Genomics

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89

Epigenetic reprogramming in pancreatic acinar cell in the absence of MIST1


ABSTRACT: Epigenetic profile of tissues is reprogrammed under diseased conditions. H3K4Me3 and H3K27Me3 represent active and repressive epigenetic marks, respectively. ChIP-seq is an effective tool to study global protein-DNA interactions. To study global epigenetic differences, we used H3K4Me3 antibody to evaluate its enrichment in pancreatic acinar cells of WT and Mist1-/- mice followed by next generation sequencing. We found specific hotspots that showed differential enrichment for H3K4Me3 both in WT and Mist1-/- mice. The data show that pancreatic acinar cells are epigenetically reprogrammed under stressed cellular conditions. Global H3K4Me3 profiling of WT and Mist1-/- pancreatic acinar cells using ChIP-seq.

ORGANISM(S): Mus musculus  

SUBMITTER: Rashid Mehmood  Christopher Pin    

PROVIDER: E-GEOD-49113 | ArrayExpress| 2014-09-06

SECONDARY ACCESSION(S): SRP028160GSE49113PRJNA213043

REPOSITORIES: GEO, ArrayExpress, ENA

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