Transcriptomics

Dataset Information

300

Murine Schistosoma-Induced Pulmonary Hypertension: RNA-seq Data


ABSTRACT: Whole lung RNA-seq of 8 mice with experimental Schistosoma-induced pulmonary hypertension, compared to 8 control mice. All mice on a C57Bl6/J background. 3 schisto-PH and 3 control mice (#s 1-3 in each group) were also processed by Affy microarray and separately submitted. 3 of the mice in each group (labeled 1D11) were also treated with the pan-TGF-beta neutralizing antibody 1D11. Illumina HiSeq 2000 used. Data published in: Protective Role of IL6 in Vascular Remodeling in Schistosoma-Pulmonary Hypertension. Graham BB, Chabon J, Kumar R, Kolosionek E, Gebreab L, Debella E, Edwards M, Diener K, Shade T, Bifeng G, Bandeira A, Butrous G, Jones K, Geraci M, Tuder RM. Am J Respir Cell Mol Biol. 2013 Jul 1. [Epub ahead of print] PMID: 23815102 Whole lung transcriptome of 8 mice with experimental Schistosoma-induced pulmonary hypertension, compared to 8 control mice. All mice on a C57Bl6/J background.

ORGANISM(S): Mus musculus  

SUBMITTER: Jacob Chabon   Brian Graham  Brian B Graham 

PROVIDER: E-GEOD-49114 | ArrayExpress | 2013-07-23

SECONDARY ACCESSION(S): SRP028161GSE49114PRJNA213046

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications

Protective role of IL-6 in vascular remodeling in Schistosoma pulmonary hypertension.

Graham Brian B BB   Chabon Jacob J   Kumar Rahul R   Kolosionek Ewa E   Gebreab Liya L   Debella Elias E   Edwards Michael M   Diener Katrina K   Shade Ted T   Bifeng Gao G   Bandeira Angela A   Butrous Ghazwan G   Jones Kenneth K   Geraci Mark M   Tuder Rubin M RM  

American journal of respiratory cell and molecular biology 20131201 6


Schistosomiasis is one of the most common causes of pulmonary arterial hypertension worldwide, but the pathogenic mechanism by which the host inflammatory response contributes to vascular remodeling is unknown. We sought to identify signaling pathways that play protective or pathogenic roles in experimental Schistosoma-induced pulmonary vascular disease via whole-lung transcriptome analysis. Wild-type mice were experimentally exposed to Schistosoma mansoni ova by intraperitoneal sensitization fo  ...[more]

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