Transcriptomics

Dataset Information

15

The prognostic and predictive value of a six-microRNA-based classifier in stage II colon cancer


ABSTRACT: microRNA profiling of colon tumor tissues vs adjacent normal tissues 40 paired tumor and adjacent normal tissues of stage Ⅱ colon caner

ORGANISM(S): Homo sapiens  

SUBMITTER: Junhang Luo   Huiyun Wang  Zhenhua Chen  Dan Xie 

PROVIDER: E-GEOD-49246 | ArrayExpress | 2013-11-29

SECONDARY ACCESSION(S): GSE49246PRJNA213381

REPOSITORIES: GEO, ArrayExpress

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Publications

Prognostic and predictive value of a microRNA signature in stage II colon cancer: a microRNA expression analysis.

Zhang Jia-Xing JX   Song Wu W   Chen Zhen-Hua ZH   Wei Jin-Huan JH   Liao Yi-Ji YJ   Lei Jian J   Hu Ming M   Chen Geng-Zhen GZ   Liao Bing B   Lu Jian J   Zhao Hong-Wei HW   Chen Wei W   He Yu-Long YL   Wang Hui-Yun HY   Xie Dan D   Luo Jun-Hang JH  

The Lancet. Oncology 20131113 13


BACKGROUND:Current staging methods do not accurately predict the risk of disease recurrence and benefit of adjuvant chemotherapy for patients who have had surgery for stage II colon cancer. We postulated that expression patterns of multiple microRNAs (miRNAs) could, if combined into a single model, improve postoperative risk stratification and prediction of chemotherapy benefit for these patients. METHOD:Using miRNA microarrays, we analysed 40 paired stage II colon cancer tumours and adjacent no  ...[more]

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