Transcriptomics

Dataset Information

5

KrasG12D partially compensates for the loss of beta-catenin in MLL-AF9 AML


ABSTRACT: The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in MLL-AF9 AML. We evaluated the dependance on beta-catenin for KrasG12DMLL-AF9 leukemia. Lin-Kit+ bone marrow cells obtained from mice transplanted with primary MLL-AF9 leukemia cells and KRasG12DMLL-AF9 leukemia cells were assessed for gene expression in the presence or absence of beta-catenin

ORGANISM(S): Mus musculus  

SUBMITTER: Cherry E Ng   Demetrios Kalaitzidis  Scott Armstrong  Amit Sinha 

PROVIDER: E-GEOD-49248 | ArrayExpress | 2014-07-02

SECONDARY ACCESSION(S): GSE49248PRJNA213401

REPOSITORIES: GEO, ArrayExpress

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Publications

KRas(G12D)-evoked leukemogenesis does not require β-catenin.

Ng C E L CE   Sinha A A   Krivtsov A A   Dias S S   Chang J J   Armstrong S A SA   Kalaitzidis D D  

Leukemia 20131105 3


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