Ontology highlight
ABSTRACT:
SUBMITTER: Martin Enge Jian Yan
PROVIDER: E-GEOD-49402 | ArrayExpress | 2013-08-15
SECONDARY ACCESSION(S): GSE49402SRP028819PRJNA215231
REPOSITORIES: GEO, ArrayExpress, ENA
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Yan Jian J Enge Martin M Whitington Thomas T Dave Kashyap K Liu Jianping J Sur Inderpreet I Schmierer Bernhard B Jolma Arttu A Kivioja Teemu T Taipale Minna M Taipale Jussi J
Cell 20130801 4
During cell division, transcription factors (TFs) are removed from chromatin twice, during DNA synthesis and during condensation of chromosomes. How TFs can efficiently find their sites following these stages has been unclear. Here, we have analyzed the binding pattern of expressed TFs in human colorectal cancer cells. We find that binding of TFs is highly clustered and that the clusters are enriched in binding motifs for several major TF classes. Strikingly, almost all clusters are formed aroun ...[more]