Dataset Information


Effect of H19 Knockdown by siRNA on gene expression in C2C12 cells

ABSTRACT: We used microarrays to characterize the global changes in gene expression in C2C12 cells due to siRNA knockdown of long non-coding RNA H19 Control siRNA or siRNA specific for mouse H19 were transfected into day1 differentiating C2C12 myoblasts in triplicates. 40 H later total RNAs were isolated and subjected with microarray analysis.

ORGANISM(S): Mus musculus  

SUBMITTER: Yingqun Huang   Chaochun Liu  Chong Qiao  Amanda N Kallen  Wang Min  Haifeng Zhang  Jing Ma  Richard I Gregory  Jie Xu  haifeng zhang  Ye Ding  Lingeng Lu  Anton M Bennett  Jae-Sung Yi  Xiao-Bo Zhou  Lei Yan 

PROVIDER: E-GEOD-49535 | ArrayExpress | 2013-09-30



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Abundantly expressed in fetal tissues and adult muscle, the developmentally regulated H19 long noncoding RNA (lncRNA) has been implicated in human genetic disorders and cancer. However, how H19 acts to regulate gene function has remained enigmatic, despite the recent implication of its encoded miR-675 in limiting placental growth. We noted that vertebrate H19 harbors both canonical and noncanonical binding sites for the let-7 family of microRNAs, which plays important roles in development, cance  ...[more]

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