Dataset Information


Stretch responsive miRNAs in human aortic valve interstitial cells

ABSTRACT: miRNA-Sequencing was performed on human aortic valve interestitial cells (AVICs) exposed to 14% stretch at 1 hz or static conditions for 24h. Six static control and six samples exposed to cyclic stretch 14% for 24h

ORGANISM(S): Homo sapiens  

SUBMITTER: Vishal Nigam  

PROVIDER: E-GEOD-49558 | ArrayExpress | 2015-01-09



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The stretch responsive microRNA miR-148a-3p is a novel repressor of IKBKB, NF-κB signaling, and inflammatory gene expression in human aortic valve cells.

Patel Vishal V   Carrion Katrina K   Hollands Andrew A   Hinton Andrew A   Gallegos Thomas T   Dyo Jeffrey J   Sasik Roman R   Leire Emma E   Hardiman Gary G   Mohamed Salah A SA   Nigam Sanjay S   King Charles C CC   Nizet Victor V   Nigam Vishal V  

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20150128 5

Bicuspid aortic valves calcify at a significantly higher rate than normal aortic valves, a process that involves increased inflammation. Because we have previously found that bicuspid aortic valve experience greater stretch, we investigated the potential connection between stretch and inflammation in human aortic valve interstitial cells (AVICs). Microarray, quantitative PCR (qPCR), and protein assays performed on AVICs exposed to cyclic stretch showed that stretch was sufficient to increase exp  ...[more]

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