Transcriptomics,Multiomics

Dataset Information

3

Transcription profiling by array of rat liver after treatment with pregnenolone 16alpha-carbonitrile


ABSTRACT: Activation of the pregnane X receptor (NR1I2) by drugs and other xenobiotics stimulates (or suppresses) expression of numerous genes involved in the metabolic elimination of foreign compounds and some toxic endogenous substrates. We used microarray analysis to identify genes whose expression in rat liver was significantly altered by pregnenolone 16alpha-carbonitrile (PCN) treatment. Experiment Overall Design: We chose to profile the gene expression pattern in the livers of adult rats to test the idea that PCN counteracts a wide variety of stresses by activating genes apart from drug metabolism.

OTHER RELATED OMICS DATASETS IN: PRJNA96711

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Linda C. Quattrochi  

PROVIDER: E-GEOD-4959 | ArrayExpress | 2007-11-29

SECONDARY ACCESSION(S): GDS2094GDS2093GSE4959PRJNA96711

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-4959.README.txt Txt
E-GEOD-4959.idf.txt Idf
E-GEOD-4959.processed.1.zip Processed
E-GEOD-4959.sdrf.txt Txt
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Publications

Identification of genes controlled by the pregnane X receptor by microarray analysis of mRNAs from pregnenolone 16alpha-carbonitrile-treated rats.

Guzelian Jeffrey J   Barwick Joyce L JL   Hunter Lawrence L   Phang Tzu L TL   Quattrochi Linda C LC   Guzelian Philip S PS  

Toxicological sciences : an official journal of the Society of Toxicology 20060922 2


Mammalian liver contains a pregnane X receptor (PXR, NR1I2), which binds drugs and other xenobiotics, and stimulates (or suppresses) expression of numerous genes involved in the metabolic elimination of foreign compounds and some toxic endogenous substances. In the present study, we used microarray analysis to identify genes whose expression in rat liver was significantly altered by pregnenolone 16alpha-carbonitrile (PCN) treatment. PCN is a synthetic steroid that induces cytochrome P4503A expre  ...[more]

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