Transcriptomics,Multiomics

Dataset Information

92

TARBP2 HITS-CLIP


ABSTRACT: In order to identify TARBP2 binding sites on endogenous RNA, we performed HITS-CLIP on a myc-tagged TARBP2 expressing cell-line (transient transfection) Cells were transfected with tagged TARBP2 vector (Origene) and 48-hr post-transfection, they were subjected to the HITS-CLIP procedure (Licatalosi D, et al. 2008, Nature 456:464-U22)

OTHER RELATED OMICS DATASETS IN: E-GEOD-49608

ORGANISM(S): Homo sapiens  

SUBMITTER: H Goodarzi  Hani Goodarzi   L Fish   C G Buss   S Zhang   S F Tavazoie   S Tavazoie    

PROVIDER: E-GEOD-49648 | ArrayExpress| 2014-09-06

SECONDARY ACCESSION(S): GSE49648SRP028595PRJNA214606

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications

Metastasis-suppressor transcript destabilization through TARBP2 binding of mRNA hairpins.

Goodarzi Hani H   Zhang Steven S   Buss Colin G CG   Fish Lisa L   Tavazoie Saeed S   Tavazoie Sohail F SF  

Nature 20140709 7517


Aberrant regulation of RNA stability has an important role in many disease states. Deregulated post-transcriptional modulation, such as that governed by microRNAs targeting linear sequence elements in messenger RNAs, has been implicated in the progression of many cancer types. A defining feature of RNA is its ability to fold into structures. However, the roles of structural mRNA elements in cancer progression remain unexplored. Here we performed an unbiased search for post-transcriptional modula  ...[more]

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