Dataset Information


Transcriptome analysis of Cox4-2 knockout mice after OVA challenge

ABSTRACT: Cytochrome c oxidase (COX) is a 13-subunit enzyme that is a key complex of the oxidative phosphorylation system of the mitochondria, which generates the vast majority of the energy of the cell.COX subunit IV is the largest nuclear-encode subunit with important regulatory functions concerning energy metabolism. COX4-2 has been knocked out. Our study indicated strong expression of Cox4-2 in lung and therefore we test this mutant line under OVA-challenge conditions expecting a new asthma mouse model. Total RNA obtained from 1/2 lung of 4 female mice of each analysed group (widltype, wildtype challenged, mutant, mutant challenged)

ORGANISM(S): Mus musculus  

SUBMITTER: Marion Horsch   Martin Irmler  Johannes Beckers 

PROVIDER: E-GEOD-49694 | ArrayExpress | 2015-07-15



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