Transcriptomics

Dataset Information

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Liver differentially expressed genes between microsomic and control inbred mice at birth


ABSTRACT: To understand the processes involved in the natural development of microsomic imbred mice, a whole genome microarray expression profiling of mouse liver was performed. Total RNA of liver from C57BL/6J microsomic mice of both sexes were extracted and compared with total RNA of liver from normal (control) mice of both sexes.

ORGANISM(S): Mus musculus  

SUBMITTER: Alexandra Calle   Alfonso Gutiérrez-Adán  Belén Pintado  Ricardo Laguna-Barraza  Irene López-Vidriero  Alberto Miranda Bedate  Ángela P López-Cardona 

PROVIDER: E-GEOD-49876 | ArrayExpress | 2014-06-04

SECONDARY ACCESSION(S): GSE49876PRJNA215225

REPOSITORIES: GEO, ArrayExpress

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Publications

Transcriptome profiling of liver of non-genetic low birth weight and long term health consequences.

Miranda Alberto A   López-Cardona Angela P AP   Laguna-Barraza Ricardo R   Calle Alexandra A   López-Vidriero Irene I   Pintado Belén B   Gutiérrez-Adán Alfonso A  

BMC genomics 20140501


BACKGROUND: It is believed that the main factors of low prenatal growth in mammals are genetic and environmental. We used isogenic mice maintained in standard conditions to analyze how natural non-genetic microsomia (low birth weight) is produced in inbred mice and its long term effect on health. To better understand the molecular basis of non-genetic microsomia, we undertook transcriptome profiling of both male and female livers from small and normal size mice at birth. RESULTS: Naturally occur  ...[more]

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