Dataset Information


A time course of icSARS CoV, SARS MA15 wild type and SARS BatSRBD mutant virus infections of C57BL6 mice

ABSTRACT: The purpose of this experiment was to investigate the transcriptional differences between mice infected with icSARS CoV, SARS MA15 wild type or SARS BatSRBD viruses. Overview of Experiment: Groups of 20 week old C57BL6 mice were infected with icSARS CoV, Wild Type SARS MA15 or SARS BatSRBD mutant viruses. Infections were done at 10^4 PFU or 10^5 PFU or time-matched mock infected. Time points were 1, 2, 4 and 7 d.p.i. There were 3-5 animals/dose/time point. Lung samples were collected for virus load, transcriptional and proteomics analysis. Weight loss and animal survival were also monitored.

ORGANISM(S): Mus Musculus

SUBMITTER: Lynn Law   Ralph Baric  Jean Chang  Michael Katze  Lisa Gralinski 

PROVIDER: E-GEOD-50000 | ArrayExpress | 2014-02-15



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