Dataset Information


SPIB and BATF provide alternate determinants of IRF4 occupancy in Diffuse Large B-cell Lymphoma linked to disease heterogeneity.

ABSTRACT: Gene expression from OCI-LY3 cells 48hrs after knock down of SPIB. 2 samples analysed (scramble and siRNA knock down), each with a single repeat.

ORGANISM(S): Homo sapiens  

SUBMITTER: Reuben M Tooze   Matthew A Care  Matthew Anthony Care 

PROVIDER: E-GEOD-50015 | ArrayExpress | 2014-06-03



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SPIB and BATF provide alternate determinants of IRF4 occupancy in diffuse large B-cell lymphoma linked to disease heterogeneity.

Care Matthew A MA   Cocco Mario M   Laye Jon P JP   Barnes Nicholas N   Huang Yuanxue Y   Wang Ming M   Barrans Sharon S   Du Ming M   Jack Andrew A   Westhead David R DR   Doody Gina M GM   Tooze Reuben M RM  

Nucleic acids research 20140529 12

Interferon regulatory factor 4 (IRF4) is central to the transcriptional network of activated B-cell-like diffuse large B-cell lymphoma (ABC-DLBCL), an aggressive lymphoma subgroup defined by gene expression profiling. Since cofactor association modifies transcriptional regulatory input by IRF4, we assessed genome occupancy by IRF4 and endogenous cofactors in ABC-DLBCL cell lines. IRF4 partners with SPIB, PU.1 and BATF genome-wide, but SPIB provides the dominant IRF4 partner in this context. Upon  ...[more]

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