Transcriptomics

Dataset Information

242

Gene expression data of untreated and RA-treated wild type and RXRα-deficient mice liver


ABSTRACT: Our project focuses on retinoic acid (RA) effect on hepatic lipid homeostasis. Even though RA has more than one receptor including retinoids x receptor (RXR) and retinoic acid receptor (RAR), most probably, RA effect on lipid homeostasis is mediated by RXR and its partners such as PXR, FXR, and PPAR. So we treated the wild type and RXRα-knockout mice by retinoic acid to check the global gene expression especially for lipid homeostasis genes. We used microarrays to observe the global gene expression underlying hepatic lipid homeostasis. We treated both the wild type and RXRα-KO mice with normal diet and RA-containing diet for 7 days. For each group, three replicates were done. Liver total RNA were used to test global gene expression by microarray.

REANALYSED by: E-GEOD-50028

ORGANISM(S): Mus musculus  

SUBMITTER: Qi Zhan   Lei Gong  Yuqi He  Yanliu Lu  Yu-Jui Y Wan  Hui-Xin Liu  Lois Lehman-McKeeman 

PROVIDER: E-GEOD-50028 | ArrayExpress | 2013-08-21

SECONDARY ACCESSION(S): GSE50028PRJNA215841

REPOSITORIES: GEO, ArrayExpress

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Publications

The role of retinoic acid in hepatic lipid homeostasis defined by genomic binding and transcriptome profiling.

He Yuqi Y   Gong Lei L   Fang Yaping Y   Zhan Qi Q   Liu Hui-Xin HX   Lu Yanliu Y   Guo Grace L GL   Lehman-McKeeman Lois L   Fang Jianwen J   Wan Yu-Jui Yvonne YJ  

BMC genomics 20130828


The eyes and skin are obvious retinoid target organs. Vitamin A deficiency causes night blindness and retinoids are widely used to treat acne and psoriasis. However, more than 90% of total body retinol is stored in liver stellate cells. In addition, hepatocytes produce the largest amount of retinol binding protein and cellular retinoic acid binding protein to mobilize retinol from the hepatic storage pool and deliver retinol to its receptors, respectively. Furthermore, hepatocytes express the hi  ...[more]

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