Transcriptomics

Dataset Information

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YAP conveys an invasive phenotype to clear cell renal cell carcinoma cell lines via endothelin-2


ABSTRACT: To determine the biological mechanisms underlying the oncogenic properties of YAP in ccRCC the human ccRCC cell line MZ1774 was transduced with lentivirus containing a shRNA-cassette targeting YAP-mRNA. Expression profiles of MZ1774 YAP knockdown cells were compared to mock-transduced control cells. Total RNA from MZ1774 cells stably expressing shRNA directed against YAP compared to mock-transduced MZ1174 cells

ORGANISM(S): Homo sapiens  

SUBMITTER: Moritz Kebschull  Georg Feldmann   Ute Schütte    

PROVIDER: E-GEOD-50053 | ArrayExpress | 2014-12-23

SECONDARY ACCESSION(S): GSE50053PRJNA215872

REPOSITORIES: GEO, ArrayExpress

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Publications

Hippo signaling mediates proliferation, invasiveness, and metastatic potential of clear cell renal cell carcinoma.

Schütte Ute U   Bisht Savita S   Heukamp Lukas C LC   Kebschull Moritz M   Florin Alexandra A   Haarmann Jens J   Hoffmann Per P   Bendas Gerd G   Buettner Reinhard R   Brossart Peter P   Feldmann Georg G  

Translational oncology 20140304 2


Recent work has identified dysfunctional Hippo signaling to be involved in maintenance and progression of various human cancers, although data on clear cell renal cell carcinoma (ccRCC) have been limited. Here, we provide evidence implicating aberrant Hippo signaling in ccRCC proliferation, invasiveness, and metastatic potential. Nuclear overexpression of the Hippo target Yes-associated protein (YAP) was found in a subset of patients with ccRCC. Immunostaining was particularly prominent at the t  ...[more]

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