Transcriptomics

Dataset Information

5

Expression data from human Th1 and Th1Th17 cells


ABSTRACT: We previously demonstrated that Th1Th17 cells are highly permissive to HIV-1, whereas Th1 cells are relatively resistant. Here, we investigated molecular mechanisms underlying these differences. Superior HIV replication in Th1Th17 vs. Th1 cells was regulated by entry and post-entry mechanisms. We used microarrays to detail the gene expression signatures caracterizing Th1 cells from Th1Th17. Primary human Th1 (CXCR3+CCR6- phenotype) and Th1Th17 (CXCR3+CCR6- phenotype) CD4+ T-cells were isolated by flow cytometry from HIV-uninfected, healthy donors. Cells were stimulated via CD3/CD28 for 3 days. The RNA was extracted and hybridized on the GeneChip® Human Genome U133 Plus 2.0 Array (Affymetrix).

ORGANISM(S): Homo sapiens  

SUBMITTER: Mohammad-Ali Jenabian   Cécile Tremblay  Annie Bernier  Patricia Monteiro  Petronela Ancuta  Annie Gosselin  Jean-Philippe Goulet  Jean-Pierre Routy  Sandrina DaFonseca  Vanessa S Wacleche  Aurélie Cleret-Buhot 

PROVIDER: E-GEOD-50175 | ArrayExpress | 2013-08-26

SECONDARY ACCESSION(S): GSE50175PRJNA216967

REPOSITORIES: GEO, ArrayExpress

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