Transcriptomics

Dataset Information

2

Molecular-guided therapy predictions reveal drug resistance phenotypes and treatment alternatives in malignant peripheral nerve sheath tumors


ABSTRACT: Use existing public data, cell lines and patient tumors with a personalized medicine approach to predict effective therapies for treatment of Neurofibroma tumors. Compare expression profile to reference set to identify over expressed genes that are drugable targets.

ORGANISM(S): Homo sapiens  

SUBMITTER: David Cherba   Jacqueline Peacock  Matt Steensma 

PROVIDER: E-GEOD-50208 | ArrayExpress | 2014-07-22

SECONDARY ACCESSION(S): GSE50208PRJNA217321

REPOSITORIES: GEO, ArrayExpress

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Publications

Molecular-guided therapy predictions reveal drug resistance phenotypes and treatment alternatives in malignant peripheral nerve sheath tumors.

Peacock Jacqueline D JD   Cherba David D   Kampfschulte Kevin K   Smith Mallory K MK   Monks Noel R NR   Webb Craig P CP   Steensma Matthew M  

Journal of translational medicine 20130917


Malignant peripheral nerve sheath tumors (MPNST) are rare highly aggressive sarcomas that affect 8-13% of people with neurofibromatosis type 1. The prognosis for patients with MPNST is very poor. Despite TOP2A overexpression in these tumors, doxorubicin resistance is common, and the mechanisms of chemotherapy resistance in MPNST are poorly understood. Molecular-guided therapy prediction is an emerging strategy for treatment refractory sarcomas that involves identification of therapy response and  ...[more]

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