Transcriptomics

Dataset Information

5

Expression data from Mst knockout embryoid bodies and wild type embryoid bodies


ABSTRACT: Mst1/Mst2 are central components of Hippo pathway. We examined the role of Mst1/Mst2 in ES cell differentiation. In this data set, we include expression data from day 4 and day 8 Mst1/Mst2 knockout ES cell formed embryoid bodies and wild type embryoid body controls. total 4 samples.

ORGANISM(S): Mus musculus  

SUBMITTER: Peng Li   Ping Yuan 

PROVIDER: E-GEOD-50219 | ArrayExpress | 2014-01-02

SECONDARY ACCESSION(S): GSE50219PRJNA217311

REPOSITORIES: GEO, ArrayExpress

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Publications

Functional role of Mst1/Mst2 in embryonic stem cell differentiation.

Li Peng P   Chen Ying Y   Mak Kinglun Kingston KK   Wong Chun Kwok CK   Wang Chi Chiu CC   Yuan Ping P  

PloS one 20131105 11


The Hippo pathway is an evolutionary conserved pathway that involves cell proliferation, differentiation, apoptosis and organ size regulation. Mst1 and Mst2 are central components of this pathway that are essential for embryonic development, though their role in controlling embryonic stem cells (ES cells) has yet to be exploited. To further understand the Mst1/Mst2 function in ES cell pluripotency and differentiation, we derived Mst1/Mst2 double knockout (Mst-/-) ES cells to completely perturb H  ...[more]

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