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Transcriptomic analysis of early response of rat brain orthotopic tumors after synchrotron microbeam irradiation (MRT)

ABSTRACT: The aim of this study was to identify the transcriptomic response 6 hours after the MRT irradiation, in normal brain tissue (11 samples) and in glioma tissue (11 samples), in rat. The orthotopic tumor-bearing rats were either treated with MRT radiation (six MRT-tumors), or untreated (five No irradiated tumors). The contralateral half hemisphere without tumor received the MRT treatment for six rats (6 MRT-Contralateral samples) and no irradiation for five rats (5 Untreated contralateral samples). Six hours after treatment, the tumors and their controlateral regions were resected and analysed for transcriptomic response.

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Céline Le Clec’h  Laurent Pelletier   Didier WION   Michèle El Atifi   Anaïk Moisan   Audrey Bouchet   Géraldine Le Duc   Nathalie Sakakini   Pierre Deman   Elke Brauer   Pascal Rihet    

PROVIDER: E-GEOD-50478 | ArrayExpress | 2015-09-01



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