Transcriptomics,Genomics

Dataset Information

414

Rrp6l1-2 project


ABSTRACT: 1, Using mRNA-Seq to get expression profiling of rrp6l1-2 mutant and Col-0 wild-type (WT); 2,Using MethylC-Seq to provide single-base resolution of DNA methylation status in rrp6l1-2 mutant; 3, Using small RNA-Seq(sRNA-Seq) to get small RNA profiling of rrp6l1-2 and WT mRNA-Seq: 2 samples examined, WT and rrp6l1-2 mutant; MethylC-Seq: 1 sample examined, rrp6l1-2 mutant; small RNA-Seq: 2 samples examined, WT and rrp6l1-2 mutant

ORGANISM(S): Arabidopsis thaliana  

SUBMITTER: Jian-Kang Zhu   Huiming Zhang  Kai Tang 

PROVIDER: E-GEOD-50486 | ArrayExpress | 2014-04-16

SECONDARY ACCESSION(S): GSE50486SRP029364PRJNA217719

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications

An Rrp6-like protein positively regulates noncoding RNA levels and DNA methylation in Arabidopsis.

Zhang Huiming H   Tang Kai K   Qian Weiqiang W   Duan Cheng-Guo CG   Wang Bangshing B   Zhang Heng H   Wang Pengcheng P   Zhu Xiaohong X   Lang Zhaobo Z   Yang Yu Y   Zhu Jian-Kang JK  

Molecular cell 20140410 3


Rrp6-mediated nuclear RNA surveillance tunes eukaryotic transcriptomes through noncoding RNA degradation and mRNA quality control, including exosomal RNA decay and transcript retention triggered by defective RNA processing. It is unclear whether Rrp6 can positively regulate noncoding RNAs and whether RNA retention occurs in normal cells. Here we report that AtRRP6L1, an Arabidopsis Rrp6-like protein, controls RNA-directed DNA methylation through positive regulation of noncoding RNAs. Discovered  ...[more]

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