Transcriptomics

Dataset Information

6

Melanoma brain metastases and matched extracranial metastases


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens  

SUBMITTER: Guo Chen  

PROVIDER: E-GEOD-50496 | ArrayExpress | 2014-05-08

SECONDARY ACCESSION(S): GSE50496PRJNA217773

REPOSITORIES: GEO, ArrayExpress

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Publications

Molecular profiling of patient-matched brain and extracranial melanoma metastases implicates the PI3K pathway as a therapeutic target.

Chen Guo G   Chakravarti Nitin N   Aardalen Kimberly K   Lazar Alexander J AJ   Tetzlaff Michael T MT   Wubbenhorst Bradley B   Kim Sang-Bae SB   Kopetz Scott S   Ledoux Alicia A AA   Gopal Y N Vashisht YN   Pereira Cristiano Goncalves CG   Deng Wanleng W   Lee Ju-Seog JS   Nathanson Katherine L KL   Aldape Kenneth D KD   Prieto Victor G VG   Stuart Darrin D   Davies Michael A MA  

Clinical cancer research : an official journal of the American Association for Cancer Research 20140506 21


An improved understanding of the molecular pathogenesis of brain metastases, one of the most common and devastating complications of advanced melanoma, may identify and prioritize rational therapeutic approaches for this disease. In particular, the identification of molecular differences between brain and extracranial metastases would support the need for the development of organ-specific therapeutic approaches.Hotspot mutations, copy number variations (CNV), global mRNA expression patterns, and  ...[more]

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