Transcriptomics

Dataset Information

121

Human Esophageal Squamous Cell Cancer Cell line: Control vs. mir203 expression vector Transfected


ABSTRACT: Transcriptional profiling of Human Esophageal Squamous Cell Cancer Cell line (KYSE520) comparing mock transfectant (KYSE520 Mock②) with cells transfected with a mir203 expression vector (KYSE520 miR203⑥) KYSE520 Mock② VS KYSE520 miR203⑥

ORGANISM(S): Homo sapiens  

SUBMITTER: Satoshi Kondo   Tomoyuki Okumura 

PROVIDER: E-GEOD-50615 | ArrayExpress | 2014-08-22

SECONDARY ACCESSION(S): GSE50615PRJNA218092

REPOSITORIES: GEO, ArrayExpress

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Publications

MicroRNA-203 inhibits the progression of esophageal squamous cell carcinoma with restored epithelial tissue architecture in vivo.

Okumura Tomoyuki T   Shimada Yutaka Y   Moriyama Makoto M   Takei Yoshinori Y   Omura Tetsuya T   Sekine Shinichi S   Nagata Takuya T   Shimizu Kazuharu K   Tsukada Kazuhiro K  

International journal of oncology 20140402 6


MicroRNA (miR)-203 has been shown to induce squamous differentiation of epidermal stem cells through the suppression of p63. The aim of this study was to assess the tumor suppressor effect of miR-203 in esophageal squamous cell carcinoma (ESCC) with focus on the regulation of the cell fate decisions and organization of tumor tissue architecture in vivo. Our investigation establishing stable clones from ESCC cell lines with induced miR-203 expression resulted in significant growth inhibition in a  ...[more]

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