Transcriptomics,Multiomics

Dataset Information

6

Profile the RNA composition of cell-free saliva and salivary exosomes


ABSTRACT: We compared the transcriptomic content of salivary exosomes vs. whole saliva via microarray (Affymetrix HU133 plus 2.0). Unstimulated saliva samples and derived exosome-like microvesicles were obtained from 3 healthy volunteers and processed for RNA isolation and microarray analysis.

OTHER RELATED OMICS DATASETS IN: PRJNA218525

ORGANISM(S): Homo sapiens  

SUBMITTER: Jieping Yang   jieping yang  David Wong 

PROVIDER: E-GEOD-50700 | ArrayExpress | 2014-09-10

SECONDARY ACCESSION(S): GSE50700PRJNA218525

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-50700.idf.txt Idf
E-GEOD-50700.processed.1.zip Processed
E-GEOD-50700.raw.1.zip Raw
E-GEOD-50700.sdrf.txt Txt
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Publications

Detection of tumor cell-specific mRNA and protein in exosome-like microvesicles from blood and saliva.

Yang Jieping J   Wei Fang F   Schafer Christopher C   Wong David T W DT  

PloS one 20141114 11


The discovery of disease-specific biomarkers in oral fluids has revealed a new dimension in molecular diagnostics. Recent studies have reported the mechanistic involvement of tumor cells derived mediators, such as exosomes, in the development of saliva-based mRNA biomarkers. To further our understanding of the origins of disease-induced salivary biomarkers, we here evaluated the hypothesis that tumor-shed secretory lipidic vesicles called exosome-like microvesicles (ELMs) that serve as protectiv  ...[more]

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