Transcriptomics

Dataset Information

4

LncRNA and mRNA expression data involved in benzene hematotoxicity


ABSTRACT: Benzene is a ubiquitous environmental pollutant and an established human hematotoxicant and leukemogen. New insights into the pathogenesis of benzene hematotoxicity are urgently needed. Long non-coding RNA(lncRNA)can regulate gene expression and widely participate in the various physiological and pathological processes. Microarray analysis was used to identify the differentially expressed lncRNA and mRNA that were likely to be critical for benzene hematotoxicity. An integrated analysis of lncRNA and mRNA expression profiles was performed to identify key hub genes, pathways and biological processes. Peripheral blood samples were randomly obtained from four patients of chronic benzene poisoning, three benzene-exposed workers and three health controls without benzene exposure. The occupational history, age, gender, lifestyle such as smoking, drinking, recent drug use situation and medical history in each group were matched. Total RNA was extracted and an integrated analysis of lncRNA and mRNA expression profiles was performed by GeneChip Human Gene 2.0 ST Array (Affymetrix).

ORGANISM(S): Homo sapiens  

SUBMITTER: ai aa gao   Lin Tian  Ai Gao 

PROVIDER: E-GEOD-50737 | ArrayExpress | 2015-07-27

SECONDARY ACCESSION(S): GSE50737PRJNA218621

REPOSITORIES: GEO, ArrayExpress

altmetric image

Publications

Long non-coding RNA NR_045623 and NR_028291 involved in benzene hematotoxicity in occupationally benzene-exposed workers.

Bai Wenlin W   Yang Jing J   Yang Gengxia G   Niu Piye P   Tian Lin L   Gao Ai A  

Experimental and molecular pathology 20140305 3


Benzene is an established human hematotoxicant and leukemogen. New insights into the pathogenesis of benzene hematotoxicity are urgently needed. Long non-coding RNA (lncRNA) widely participate in various physiological and pathological processes. It has been shown that lncRNA plays an important role in hematologic malignancy tumorigenesis. However, the expression and biological function of lncRNA during benzene hematotoxicity progress remain largely unknown. An integrated analysis of differential  ...[more]

Similar Datasets

2011-12-31 | E-GEOD-24923 | ArrayExpress
2011-07-19 | E-GEOD-30801 | ArrayExpress
2011-07-19 | E-GEOD-30799 | ArrayExpress
2011-07-19 | E-GEOD-30798 | ArrayExpress
2013-07-01 | E-GEOD-48179 | ArrayExpress
2013-08-01 | E-GEOD-49422 | ArrayExpress
2014-03-01 | E-GEOD-51349 | ArrayExpress
2013-04-30 | E-GEOD-33794 | ArrayExpress
| GSE50967 | GEO
2018-09-06 | GSE119533 | GEO