Transcriptomics

Dataset Information

15

Transcription profiling of C57BL/6NIA mouse hippocampus to survey age-related changes in mRNA levels.


ABSTRACT: We carried out a global survey of age-related changes in mRNA levels in the C57BL/6NIA mouse hippocampus and found a difference in the hippocampal gene expression profile between 2-month-old young mice and 15-month-old middle-aged mice correlated with an age-related cognitive deficit in hippocampal-based explicit memory formation. Middle-aged mice displayed a mild but specific deficit in spatial memory in the Morris water maze. Experiment Overall Design: No technical replicates; 14 biological replicates for 15-month-old mice, 9 biological replicates for 2-month-old mice. Whole hippocampus.

ORGANISM(S): Mus musculus  

SUBMITTER: Paul Pavlidis  

PROVIDER: E-GEOD-5078 | ArrayExpress | 2007-11-27

SECONDARY ACCESSION(S): GDS2082GSE5078PRJNA95519

REPOSITORIES: GEO, ArrayExpress

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Publications

Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice.

Verbitsky Miguel M   Yonan Amanda L AL   Malleret Gaël G   Kandel Eric R ER   Gilliam T Conrad TC   Pavlidis Paul P  

Learning & memory (Cold Spring Harbor, N.Y.) 20040501 3


We have carried out a global survey of age-related changes in mRNA levels in the C57BL/6NIA mouse hippocampus and found a difference in the hippocampal gene expression profile between 2-month-old young mice and 15-month-old middle-aged mice correlated with an age-related cognitive deficit in hippocampal-based explicit memory formation. Middle-aged mice displayed a mild but specific deficit in spatial memory in the Morris water maze. By using Affymetrix GeneChip microarrays, we found a distinct p  ...[more]

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