Dataset Information


Effects of gentamycin on gene expression of kidney in SD rats

ABSTRACT: To investigate the gene expression profile of genamycin induced nephrotoxicity in a time-series aspect, SD rats were administrated once daily with saline, genamycin 80 mgkg for 28 consecutive days by intramuscular injection folled by 28 days recovery. Kidney samples were collected for microarray analysis and histological examination. There were 4360 and 4323 regulated genes for females and males, respectively, however, the overlapping expression genes coregluated at each time point were few, with 2 for females and 12 for males. By Principle Component Analysis and Hierarchical Cluster, the gene expression patterns were apparently associated with the disease stage of the nephrotoxicity,while GO Annotation showed the biological processes were specific to each course of this nephrotoxicity.Our studymapped the different gene expression patterns at the initiation, development and recovery stage of gentamycin-induced nephrotoxicity Gene expression in kidney from SD rats administrated once daily with saline or 80 mg/kg genamycin by intramuscular injection for 28 consecutive days follwed by 28 days recovery were measured using Aglient Rat Whole Genome 4*44 k array

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Yunliang Qiu   Wenxin Dong  min hong  Jing Ma  Min Hong  Ching-hung Hsu 

PROVIDER: E-GEOD-50804 | ArrayExpress | 2013-09-13



Similar Datasets

| GSE50804 | GEO
2012-02-15 | E-MTAB-983 | ArrayExpress
2012-02-01 | E-MTAB-826 | ArrayExpress
2015-07-27 | PXD001265 | Pride
2011-01-30 | E-GEOD-25098 | ArrayExpress
2019-06-27 | PXD012013 | Pride
2012-01-01 | E-GEOD-26518 | ArrayExpress
2017-07-26 | PXD005823 | Pride
2012-03-01 | E-GEOD-36161 | ArrayExpress
2020-04-08 | PXD014285 | Pride