Dataset Information


ChIP-seq of MDA-MB-134 cell line

ABSTRACT: We performed ChIP seq experiment in MDA-MB-134 cell line in order to map the estrogen receptor alpha (ER) binding sites following the estrogen treatment in an ILC model. We have characterized the genome wide recruit of ER and scaned the binding sites for the presence of cofactor motifs. The binding peaks were also correlated to E2 regulated genes in this ILC model. Four samples were subjected to high throughput sequencing: E-ER (estrogen treated followed by ER IP), E-IgG (estrogen treated followed by IgG), V-ER (EtOH treated followed by ER IP) and Input (MCF7 genomic DNA)

ORGANISM(S): Homo sapiens  

SUBMITTER: Matthew J Sikora   Amir Bahreini 

PROVIDER: E-GEOD-51022 | ArrayExpress | 2014-01-15



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Invasive lobular carcinoma cell lines are characterized by unique estrogen-mediated gene expression patterns and altered tamoxifen response.

Sikora Matthew J MJ   Cooper Kristine L KL   Bahreini Amir A   Luthra Soumya S   Wang Guoying G   Chandran Uma R UR   Davidson Nancy E NE   Dabbs David J DJ   Welm Alana L AL   Oesterreich Steffi S  

Cancer research 20140114 5

Invasive lobular carcinoma (ILC) is a histologic subtype of breast cancer that is frequently associated with favorable outcomes, as approximately 90% of ILC express the estrogen receptor (ER). However, recent retrospective analyses suggest that patients with ILC receiving adjuvant endocrine therapy may not benefit as much as patients with invasive ductal carcinoma. On the basis of these observations, we characterized ER function and endocrine response in ILC models. The ER-positive ILC cell line  ...[more]

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