Transcriptomics

Dataset Information

25

Ovarian Tumor Samples: mixed reference of 106 pooled ovarian samples vs. individual patient ovarian sample


ABSTRACT: The goal of the study was to identify molecular subgroups that might predict clinical outcomes in serous epithelial ovarian cancer (EOC) patients. A second objective was to identify potential therapeutic targets for serous EOC based on improved understanding of the molecular diversity of the disease. Ovarian tissues and matched peripheral blood samples were prospectively obtained from sequential patients undergoing planned gynecologic surgery at Cedars-Sinai Medical Center between 1989 and 2005. All patients underwent surgery and received adjuvant chemotherapy with a contemporaneous standard-of-care regimen. Ovarian tissue samples (n=172) were compared to a reference pool of 106 ovarian samples. Mixed reference includes normal, benign, borderline, and malignant samples.

ORGANISM(S): Homo sapiens  

SUBMITTER: Dennis Slamon   Judy Dering  Chuck Ginther  Beth Karlan 

PROVIDER: E-GEOD-51088 | ArrayExpress | 2013-12-26

SECONDARY ACCESSION(S): GSE51088PRJNA221150

REPOSITORIES: GEO, ArrayExpress

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Publications

POSTN/TGFBI-associated stromal signature predicts poor prognosis in serous epithelial ovarian cancer.

Karlan Beth Y BY   Dering Judy J   Walsh Christine C   Orsulic Sandra S   Lester Jenny J   Anderson Lee A LA   Ginther Charles L CL   Fejzo Marlena M   Slamon Dennis D  

Gynecologic oncology 20131222 2


OBJECTIVE:To identify molecular prognosticators and therapeutic targets for high-grade serous epithelial ovarian cancers (EOCs) using genetic analyses driven by biologic features of EOC pathogenesis. METHODS:Ovarian tissue samples (n = 172; 122 serous EOCs, 30 other EOCs, 20 normal/benign) collected prospectively from sequential patients undergoing gynecologic surgery were analyzed using RNA expression microarrays. Samples were classified based on expression of genes with potential relevance in  ...[more]

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