Transcriptomics

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Prospective molecular profiling of canine cancers provides a clinically relevant comparative model for evaluating precision medicine (PMed) trials


ABSTRACT: Feasibility trial to examine the ability to conduct molecular guided therapy in a geographically distributed systems within strict time constraints Canine patients were enrolled across a broad panel of tumor types where tumor samples were acquired and processed to preserve RNA quality for genomic analysis at distributed locations to predict possible effective therapies. Genomic driven therapy suggestion derived using a collection of algorithms based on tumor expression levels.

ORGANISM(S): Canis lupus  

SUBMITTER: David Vail  David Cherba   Chand Khanna1   Mark Neff   Barbara Davis   Christopher Kingsley   Brad Charles   Michael Childress   Melissa Paoloni   Jeffrey Trent   Heather Fehling   Michael Henson   Seungchan Kim   E.J. Ehrhart   Christina Mazcko   Barbara Kitchell   Leena Kumar   Susan Lana   Craig Webb    

PROVIDER: E-GEOD-51131 | ArrayExpress | 2014-04-28

SECONDARY ACCESSION(S): GSE51131PRJNA221340

REPOSITORIES: GEO, ArrayExpress

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Publications


Molecularly-guided trials (i.e. PMed) now seek to aid clinical decision-making by matching cancer targets with therapeutic options. Progress has been hampered by the lack of cancer models that account for individual-to-individual heterogeneity within and across cancer types. Naturally occurring cancers in pet animals are heterogeneous and thus provide an opportunity to answer questions about these PMed strategies and optimize translation to human patients. In order to realize this opportunity, i  ...[more]

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