Transcriptomics

Dataset Information

5

Analysis of cord blood CD4T cells


ABSTRACT: Purified CD4 T cells isolated from the cord blood were divided in subsets according to IL2R, IL7R and chemokine receptors (CCR6, CXCR3 and CCR4) and compared by whole genome microarray analysis. CD4 T cell memory subsets and Naive T cell collected from 3 donors (#480, #487, #488)

ORGANISM(S): Homo sapiens  

SUBMITTER: Richard Lo-Man  

PROVIDER: E-GEOD-51133 | ArrayExpress | 2014-06-04

SECONDARY ACCESSION(S): GSE51133PRJNA221251

REPOSITORIES: GEO, ArrayExpress

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Publications

CD4 T cells with effector memory phenotype and function develop in the sterile environment of the fetus.

Zhang Xiaoming X   Mozeleski Brian B   Lemoine Sebastien S   Dériaud Edith E   Lim Annick A   Zhivaki Dania D   Azria Elie E   Le Ray Camille C   Roguet Gwenaelle G   Launay Odile O   Vanet Anne A   Leclerc Claude C   Lo-Man Richard R  

Science translational medicine 20140501 238


The T cell compartment is considered to be naïve and dedicated to the development of tolerance during fetal development. We have identified and characterized a population of fetally developed CD4 T cells with an effector memory phenotype (TEM), which are present in cord blood. This population is polyclonal and has phenotypic features similar to those of conventional adult memory T cells, such as CD45RO expression. These cells express low levels of CD25 but are distinct from regulatory T cells be  ...[more]

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