Dataset Information


IL7R: WT vs mutant in vitro and in vivo.

ABSTRACT: The screening of putative candidate genes downstream of IL7R-INS in vitro KSL/CLP and in vivo (depicted as B-neoplasm, Notch-T-ALL, or myeloid disorder) in comparison to WT. Five-condition experiment: WT-KSL vs. INS-KSL cells; WT-CLP vs.INS-CLP; WT/ICN vs. INS/ICN; WT-CMP vs. INS-CMP. Biological replicate: each 1, One replicate per array.

ORGANISM(S): Mus musculus  

SUBMITTER: Kazuaki Yokoyama   Satoshi Kondo 

PROVIDER: E-GEOD-51211 | ArrayExpress | 2014-01-08



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In vivo leukemogenic potential of an interleukin 7 receptor α chain mutant in hematopoietic stem and progenitor cells.

Yokoyama Kazuaki K   Yokoyama Nozomi N   Izawa Kiyoko K   Kotani Ai A   Harashima Akira A   Hozumi Katsuto K   Tojo Arinobu A  

Blood 20131030 26

Somatic gain-of-function mutations in interleukin 7 receptor α chain (IL7Rα) have been described in pediatric T and B acute lymphoblastic leukemias (T/B-ALLs). Most of these mutations are in-frame insertions in the extracellular juxtamembrane-transmembrane region. By using a similar mutant, a heterozygous in-frame transmembrane insertional mutation (INS), we validated leukemogenic potential in murine hematopoietic stem/progenitor cells, using a syngeneic transplantation model. We found that ecto  ...[more]

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