Dataset Information


Methylation profiles of esophageal squamous cell carcinoma patients and cancer-free individual in Taiwan.

ABSTRACT: Genome wide DNA methylation profiling of tumor and normal samples with esophageal squamous cell carcinoma patients. The Illumina GolodenGate methylation cancer panel I was used to obtain DNA methylation profiles across approximately 1,505 CpGs in esophageal squemous cell carcinoma samples. Samples included normal, tumors and plasma samples with esophageal squamous cell carcinoma, also inculding the plasma samples with cancer-free individual. Bisulfite converted DNA from the 288 samples were hybridised to the Illumina GolodenGate methylation cancer panel I

ORGANISM(S): Homo sapiens  

SUBMITTER: Y Wang   Yi-Ching Wang  I Kuo 

PROVIDER: E-GEOD-51287 | ArrayExpress | 2014-09-11



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Network-based analysis identifies epigenetic biomarkers of esophageal squamous cell carcinoma progression.

Cheng Chun-Pei CP   Kuo I-Ying IY   Alakus Hakan H   Frazer Kelly A KA   Harismendy Olivier O   Wang Yi-Ching YC   Tseng Vincent S VS  

Bioinformatics (Oxford, England) 20140710 21

MOTIVATION:A rapid progression of esophageal squamous cell carcinoma (ESCC) causes a high mortality rate because of the propensity for metastasis driven by genetic and epigenetic alterations. The identification of prognostic biomarkers would help prevent or control metastatic progression. Expression analyses have been used to find such markers, but do not always validate in separate cohorts. Epigenetic marks, such as DNA methylation, are a potential source of more reliable and stable biomarkers.  ...[more]

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