Transcriptomics,Genomics

Dataset Information

60

Integrative study of cooperative lineage-survival oncogenes in gastric cancer


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

OTHER RELATED OMICS DATASETS IN: E-GEOD-51704

ORGANISM(S): Homo sapiens  

SUBMITTER: Niantao Deng  

PROVIDER: E-GEOD-51706 | ArrayExpress | 2014-09-05

SECONDARY ACCESSION(S): GSE51706PRJNA224584

REPOSITORIES: GEO, ArrayExpress

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Publications


OBJECTIVE: Gastric cancer (GC) is a deadly malignancy for which new therapeutic strategies are needed. Three transcription factors, KLF5, GATA4 and GATA6, have been previously reported to exhibit genomic amplification in GC. We sought to validate these findings, investigate how these factors function to promote GC, and identify potential treatment strategies for GCs harbouring these amplifications. DESIGN: KLF5, GATA4 and GATA6 copy number and gene expression was examined in multiple GC cohorts.  ...[more]

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